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The present invention relates to decorative flexible packaging and in particular to a post-wrap package in which a postage meter device is concealed. More particularly the present invention relates to a package having a convoluted sheet material envelope with cover strips sealed to the envelope and a tamper-evident opening flap.
It is known to package products and advertising material in flexible packages such as re-closable bags, flexible envelopes and the like. These packages are sold by mail houses and delivered to addressees by means of delivery service. Such flexible packages have the advantage that they can be torn open and left at the customer's place of residence. This enables the addressee to open the package to access the enclosed object, or, if the package contains advertising material, to gain access to the advertising material after removing the package cover.
It is also known to add pre-printed or company specific information to the outer envelope of such packages. This enables the addressee to associate the enclosed object with the particular company or the like, and enhances customer satisfaction.
European Patent No. 0 052 822 B1 describes a package for mailing products and the like. This package includes a flat envelope which surrounds an article or product and is provided with a cover strip sealably fastened to the bottom edge of the envelope. The cover strip is provided with a tear strip which can be torn along a tear line to remove the cover strip from the envelope. Furthermore the package has tamper evident features, in particular a tear panel which can be torn apart to provide access to the contents of the envelope.A novel conserved motif (Ala-Ser-Pro-Thr) in the 5' untranslated region of NME1 mRNA and the effect of Thr-194 substitution on protein expression.
NME1 protein, a member of the nucleoside diphosphate-sugar kinase superfamily, has been reported as a molecular marker for poorly differentiated and malignant tumors and a prognostic factor in cancer. However, its mechanism of expression is unknown. In this study, the 5' untranslated region (UTR) of the NME1 gene was cloned and analyzed. A novel conserved motif (Ala-Ser-Pro-Thr) was found in the NME1 5' UTR by sequence alignment with other species, and was designated as DSST-motif. Furthermore, we studied the function of the DSST-motif and the regulation of NME1 gene
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